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been employed in folk medicine in curing. activity on scale and variety of bacteria and

viruses on the powder contains insect growth inhibitor, antiviral, antimalarial, bacteriostatic,
antimalarial, larvicidal, and antiviral activity (Gupta et al., 2013).

Contained inside the bark of this plant are: Nimbin, nimbidin, 6-
methoxymarginimercochenol, quercetion, and so on (Alzohairy, 2016). Neem leaf extract

containing the ingredient “hyperoside” was a universal antibiotic due to its radical-
scavenging property. These findings were better obtained with hyperoside neem leaf extract

plus chemical pharmaceutical drugs, LGH, Naproxen, and BMS-88, with conserved

polypeptide segments of the flu infection (Ahmad et al., 2016). This whole plant and its
leaves have been exceptional herbs, has been designated a title as "tree of the century" by the

United Nations (UNEP5, 2012).

Neem has previously been found to be successful in the war against SARS-COV-2, so
scientists are looking into its ability to be a treatment for SARS-related drugs. Also known as

methyl eugenol and oleate, and have been shown to inhibit SARS‐2. This inhibition is
possible by bioactive compounds present in neem that impasse to the spike protein in virus,

protease and the RNA polymerase preventing the attachment and spread of viral strands
(Kumar, 2020). Numerous combinations from the leaf extracts had high binding affinity for

the COVD-19 enzyme, the one that determines the virus's ability to replicate (Subramanian,

2020). Researches screened the species of neem plant family with potential to be effective in
anti‐SARS‐2 treatments.

ix. Giloy (Tinospora cordifolia)
Giloy plants are found in India, Sri Lanka, Myanmar, and China. The plant is from the

menispermaceae family. Guduchi is found in India that has a medicinal value in traditional
Ayurvedic therapies and is used to treat a number of ailments. Medicinal use of this plant has

skyrocketed recently, particularly in treating jaundice, skin disorders, diabetes, anaemia, and

more (Kumar, 2020; Sonkamble & Kamble, 2015). The activities can be found in the
following sections of T. cordifolia: leaves, stem, root, and flower, plus seeds and so on. In

Indian traditional medicine, this plant helps to support the general health of the immune

system and promote resistance to infections.
Stem and leaf dry extract of T. cordifolia display antiviral activity according to the MTT

assay With the help of a molecular dynamics study, scientists concluded that giloy, berberine,
tetracyclogeline, and octacosanol all exist in cordifolia She found that Berberine suppressed

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