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1.  INTRODUCTION:



                                      Globally mosquitoes are known to transmit more diseases that affect millions
               of  people  than  any  other  group  of  arthropods.  The  severity  of  infection  and  health  threat

               posed  can  be  comprehended  by  WHO’s  classification  of  mosquitoes  as  “Public  enemy

               number  one”  (WHO,  1996).  Several  life-threatening  vector  borne  diseases  i.e.  protozoan
               diseases as malaria, viral diseases as yellow fever and dengue fever and parasitic diseases as

               filariasis etc. are caused by mosquitoes. Mosquito borne disease are prevalent in about 100
               countries over the globe; and are known to infect 700,000,000 human’s annually of which

               40,000,000 people belong to India (WHO, 1996; WHO 2009). Some of these diseases like
               malaria caused by Plasmodium falciparum and dengue caused by dengue virus with adverse

               conditions of dengue hemorrhagic fever or abnormal symptoms on central nervous system

               account for serious public health threat for (Das et.al., 2007; WHO 2009). There are different
               species  of  mosquito  such  as  Anopheles,  culex,  Aedes  that  act  as  a  vector  for  different

               diseases like Chikungunya virus, Dengue Virus, Encephalitis virus, Malaria, Yellow fever,
               Zika virus and many more (Jain and Kumar, 2018). The prevalence of these sepecies can be

               contributed to their adaptive nature, as an ever-present insect this race shows ability to alter

               their needs as per any new habitat (Murugan et. al., 2011). Apart from causing pathogenicity
               in  humans  mosquitoes  are  also  known  to  cause  diseases  like  ‘fowl  pox’  in  chickens,

               ‘myxomatosis’ in rabbits, ‘rift valley’ in sheep and ‘encephalitis’ in horses and birds.
                Extracted  protein  from Bacillus  thuringiensis  and  Bacillus  sphaericus,  temephos,

               organophosphates, methoprene are some of the most used larvicides. Economic feasibility of

               these  approaches  is  also  poor  as  bacterial  product  has  a  high  cost  of  production  and
               purification (Lacy, 2007). So mostly the chemical compounds are preferred as compared to

               extracted  proteins.  The  major  use  of  chemical  insecticide  in  recent  days  to  control  the
               increasing number of vectors have a detrimental effect on beneficial insects and environment

               both.  Water  logged  places  like  drains  and  culverts,  where  mosquitoes  breed  and  rest,  are
               treated  with  pyrethroids  but  the  extreme  use  of  chemical  pesticides  is  leading  mosquito

               population undergo selection pressure due to which the mosquitoes are developing resistance

               against synthetic insecticides (Jain and Kumar, 2018). Anopheles gambiae is DTT resistance
               and hence over growing concern use of DDT has been banned (Muhammad et. al., 2021).

               Anopheles  coluzzii shows  resistance  to  permethrin  due  to  differential  expression  of
               insecticide  resistance  gene CYP6Z1  on  the  X  chromosome  locus,  increased  activity  of

               Carboxylesterase COEAE5G suggest resistance to organophosphates (Mathur et. al., 1981).



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