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Antihelmenthic activity

Acetone extract from walnut bark possesses significant activity against Eicinia feotida. Also,
ethanol, methanol and benzene extract of bark showed significant antihelmenthic activity

against Pheretima posthumana and concluded that stem bark has a maximum an
antihelmenthic activity (Upadhyay et al., 2010a).

Hepatoprotective activity
Some researchers reported that walnut polyphenols from kernel pellicle orally given to liver

damaged in mice model induced by CCL4. This result showed that polyphenols are higher

hepatoprotective agent than commonly used famous curcumin. It was found that polyphenolic
constituents were the main principal phytoconstituents present in different parts of walnut are

responsible against oxidative damage for hepatoprotective activity. Tellimagrandins I one of

the polyphenolic was found as the vital constituents as hepatoprotective agent (Hiroshi et al.,
2008).

Anticancer activity
Anticancer properties had been reported Juglone as a promising chemo preventive agent

against many cancerous cells. Researcher had done a invitro study revealed juglone as potent
cytotoxic agent against human tumor cell lines. Juglone induced apoptosis and inhibited the

growth of sarcoma cells (Ji et al., 2011). Walnut leaf, bark, green husk, fine powder as

petroleum and methanolic extract shows significant anticancer properties by growth
inhibition, antiproliferative efficiency, activation of mitochondrial death pathway, generation

of reactive oxygen species (ROS) mechanisms (Kumudhavalli et al., 2010).
Memory booster activity

Walnut enhancing the memory and learning skills and act as memory booster was reported
and concluded that it increases serotonin level in the brain which result into the advancement

in memory and learning capacity (Haider, 2011; Asadi-Shekaari, 2013). One more study
conducted showed the effect of polyphenol extracts from green husk and kernels
magnificently increases the learning and memory function of brain (Eidi, 2013; Shi, 2014).

Immunity booster activity

It has been reported that fruits of walnut increases and boosts the immunity of immune
system by increasing phagocytosis against various macrophages and enhancing proliferations

of lymphocytes (Ruijun, 2015). Hence, due to its immune boosting activity walnut can be one
of the key medicinal plant used in Covid-19 viral infections also.

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